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The study was powered for an effect size of 50%, but more recent data suggest that an effect size of 30% would have been more appropriate, and as a result, our study might have been underpowered

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Systemic corticosteroids (prednisone) may be used for more extensive disease, though they are not appropriate for maintenance due to significant adverse effects with prolonged use

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Gut-colonising microbes and their products are, therefore, important in promoting gut barrier health, and the disruption of microbial communities is associated with a number of downstream consequences (Allaire et al